منابع مشابه
Recent Advances in Hemophilia Gene Therapy
Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...
متن کاملAntifungal Therapy: New Advances in the Understanding and Treatment of Mycosis
The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane component...
متن کاملNew Horizons in Antifungal Therapy
Recent investigations have yielded both profound insights into the mechanisms required by pathogenic fungi for virulence within the human host, as well as novel potential targets for antifungal therapeutics. Some of these studies have resulted in the identification of novel compounds that act against these pathways and also demonstrate potent antifungal activity. However, considerable effort is...
متن کاملAntifungal photodynamic therapy.
In photodynamic antimicrobial chemotherapy (PACT), a combination of a sensitising drug and visible light causes selective destruction of microbial cells. The ability of light-drug combinations to kill microorganisms has been known for over 100 years. However, it is only recently with the beginning of the search for alternative treatments for antibiotic-resistant pathogens that the phenomenon ha...
متن کاملCombination antifungal therapy.
Combination Antifungal Therapy Melissa D. Johnson,* Conan MacDougall, Luis Ostrosky-Zeichner, John R. Perfect, and John H. Rex Departments of Medicine, and Pharmacy, Duke University Medical Center, Durham, and Campbell University School of Pharmacy, Buies Creek, North Carolina; Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Re-emerging Pat...
متن کاملAdvances in antiretroviral therapy.
The 14th Conference on Retroviruses and Opportunistic Infections provided a forum for presentation of state-of-the-art research on antiretroviral therapy. This year's conference marked the first public presentation of phase III trials of the lead compounds in 2 new drug classes: maraviroc (a CCR5 inhibitor) and raltegravir (an HIV-1 integrase inhibitor). These agents are likely to be approved b...
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عنوان ژورنال:
archives of clinical infectious diseasesجلد ۱، شماره ۴، صفحات ۱۶۹-۱۷۰
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